1. M. Mateus, M. L. Hammill, D. B. D. Simmons and J.-P. Desaulniers. “In vivo Injection of Reversible Optically Controlled Short Interfering RNA into Japanese Medaka Embryos (Oryzias latipes) to Regulate Gene Silencing” ACS Chem. Biol. 2024, 19, 1904-1909.

2. G. Islam, A. Gedge, R. Ibrahim, T. de Melo, L. Lara-Jacobo, T. Dlugosz, A. E. Kirkwood, D. Simmons and J.-P. Desaulniers. “The role of catchment population size, data normalization, and chronology of public health interventions on wastewater-based COVID-19 viral trends” Sci. Total Environ. 2024, 173272.

3. P. M. D’Aoust, N. Hegazy, N. T. Ramsay, M. I. Yang, H. A. Dhiyebi , E. Edwards, M. R. Servos, G. Ybazeta, M. Habash, L. Goodridge, A. Poon, E. Arts, R. S. Brown, S. J.Payne, A. Kirkwood, D. Simmons, J.-P. Desaulniers, B. Ormeci, C. Kyle, D. Bulir, T. Charles, R. M. McKay, K. Gilbride, C. Oswald, H. Peng, V. Pileggi, M. L. Wang, A. Tong, D. Orellano, C. T. DeGroot and R. Delatolla. “SARS-CoV-2 viral titer measurements in Ontario, Canada wastewaters throughout the COVID-19 pandemic” Sci. Data 2024, 11, 656.

4. I. Giorgees, V. Affe, I. Williams and J.-P. Desaulniers. “Direct Conjugation of Gallium-(III)-Corroles to short interfering RNA(siRNA) Providing Real-Time siRNA Imaging and Gene Silencing" ChemPlusChem, 2024, e202400084 ** selected for front cover art **.

5. T. De Melo, G. Islam, D. B. D. Simmons, J.-P. Desaulniers and A. E. Kirkwood. “Alternative method for monitoring and interpretation of influenza A in communities using wastewater surveillance” Front. Public Health, 2023, 11, 1141136.

6. L. Salim and J-P. Desaulniers. “Synthesis of Folate-Labeled siRNAs From a Folate Derivative Phosphoramidite” Org. Biomol. Chem. 2023, 21, 3365-3372. ** selected for front cover art **

7. C. Fernandez, I. Giorgees, E. Goss, and J-P. Desaulniers. “Effective Carrier-Free Gene-Silencing Activity of Sphingosine-Modified siRNAs” Org. Biomol. Chem. 2023, 21, 2107-2117. ** selected for front cover art **

8. M. L. Hammill, K. Tsubaki, M. Kitamura, T. Okauchi, and J.-P. Desaulniers. "Synthesis of an Ortho‐Functionalized Tetrafluorinated Azobenzene Phosphoramidite for Incorporation Into a Tetrafluorinated Azobenzene-Containing siRNA for Photocontrolled Gene Silencing" Curr. Protoc. Nucleic Acid Chem. 2023, 3, e874.

9. J.-P. Desaulniers, K. Tsubaki, M. L. Hammill, M. Kitamura, and T. Okauchi. "Synthesis of Dinucleotide Non-Symmetrical Triester Phosphate Phosphoramidites and their Incorporation within Oligonucleotides " Curr. Protoc. Nucleic Acid Chem. 2023, 3, e784. 

10. A. Varley and J.-P. Desaulniers. "Synthesis of 5’-Fluorophosphate-Modified Short-Interfering RNAs" Nucleosides Nucleotides Nucleic Acids 2022, 1-13.

11. M. L. Hammill, K. Tsubaki, Y. Wang, G. Islam, M. Kitamura, T. Okauchi, and J.-P. Desaulniers. "Synthesis, Derivatization and Photochemical Control of an ortho-Functionalized Tetrafluorinated Azobenzene-Modified siRNA" ChemBioChem 2022, 23, e202200386.

12. M. L. Hammill, G. Islam, and J-P. Desaulniers. “Synthesis of Ortho‐Functionalized Tetrachlorinated Azobenzene Phosphoramidites for Incorporation Into siRNAzos for Photocontrolled Gene Silencing” Curr. Protoc. Nucleic Acid Chem. 2022, e513.

13. M. L. Hammill, K. Tsubaki, L. Salim, A. J. Varley, I. Giorgees, M. Kitamura, T. Okauchi, and J.-P. Desaulniers. "SiRNAs with Neutral Phosphate Triester Hydrocarbon Tails Exhibit Carrier-Free Gene-Silencing Activity" ACS Med. Chem. Lett. 2022, 13, 695–700.

14. E. Arts, S. Brown, D. Bulir, T. C. Charles, C. T. DeGroot, R. Delatolla, J.-P. Desaulniers, E. A. Edwards, M. Fuzzen, K. Gilbride, J. Gilchrist, L. Goodridge, T. E. Graber, M. Habash, P. Jüni, A. Kirkwood, J. Knockleby, C. Kyle, C. Landgraff, C. Mangat, D. G. Manuel, R. M. McKay, E. Mejia, A. Mloszewska, B. Ormeci, C. Oswald, S. J. Payne, H. Peng, S. Peterson, A. F. Y. Poon, M. R. Servos, D. Simmons, J. Sun, M. Yang, and G. Ybazeta."Community Surveillance of Omicron in Ontario: Wastewater-based Epidemiology Comes of Age" 2022, Pre-print, Research Square: 10.21203/rs.3.rs-1439969/v2.

15. L. Lara-Jacobo, G. Islam, J.-P. Desaulniers, A. E. Kirkwood, and D. B. D. Simmons. "Detection of SARS-CoV-2 Proteins in Wastewater Samples by Mass Spectrometry" ACS Environ. Sci. Technol. 2022, 56, 5062–5070.

16. I. Giorgees, F. Wu, Z. Shen, and J.-P. Desaulniers. "A Dual Therapeutic System Based on Corrole-siRNA Conjugates" Org. Biomol. Chem. 2022, 20, 2626-2635. ** selected for front cover art **

17. G. Islam, A. Gedge, L. Lara-Jacobo, A. Kirkwood, D. Simmons, and J.-P. Desaulniers. "Pasteurization, storage conditions and viral concentration methods influence RT-qPCR detection of SARS-CoV-2 RNA in wastewater" Sci. Total Environ. 2022, 821, 153228.

18. M. L. Hammill, L. Salim, K. Tsubaki, A. Varley, M. Kitamura, T. Okauchi, and J.-P. Desaulniers. "Building siRNAs with Cubes: Synthesis and Evaluation of Cubane-Modified siRNAs" ChemBioChem 2021, 22, 2981-2985.

19. L. Salim, E. Goss and J.-P. Desaulniers. "Synthesis and Evaluation of Modified siRNA Molecules Containing a Novel Glucose Derivatives" RSC Advances 2021, 11, 9285–9289.

20. L. Salim and J.-P. Desaulniers. "To Conjugate or to Package? A Look at Targeted siRNA Delivery via Folate Receptors" Nucleic Acid Ther. 2021, 31, 21-38. ** selected for front cover art **

21. A. J. Varley and J.-P. Desaulniers. "Chemical Strategies for Strand Selection in Short-Interfering RNAs" RSC Advances 2021, 11, 2415–2426.

22. M.L. Hammill, G. Islam, and J.-P. Desaulniers. "Controlling Gene-Silencing with Azobenzene-Containing siRNAs (siRNAzos)" Curr. Protoc. Nucleic Acid Chem. 2020, 83, e119.

23. S. Barmaki, A. Ali, J.-P. Desaulniers, and Y. Bolshan. "Bromination of Codeine and its Derivatives: Revisiting a 95-Year Old Process" Tetrahedron Lett. 2020, 61, 152234.

24. K. Tsubaki, M. L. Hammill, A. J. Varley, M. Kitamura, T. Okauchi, and J.-P. Desaulniers. "Synthesis and Evaluation of Neutral Phosphate Triester Backbone-Modified siRNAs" ACS Med. Chem. Lett. 2020, 11, 1457–1462.

25. M. L. Hammill and J.-P. Desaulniers. "Synthesis of Azobenzene Derivative Phosphoramidites For Incorporation into Oligonucleotides" Curr. Protoc. Nucleic Acid Chem. 2020, 81, e107.

26. M. L. Hammill, G. Islam, and J.-P. Desaulniers. "Synthesis, Derivatization and Photochemical control of Ortho-Functionalized Tetrachlorinated Azoben­­­zene-Modified siRNAs"  ChemBioChem. 2020, 21, 2367-2372.

* Highlighted by the Editorial Board of SYNFACTS! *

27. A. Varley, M. L. Hammill, L. Salim, and J.-P. Desaulniers. "Effects of Chemical Modifications on siRNA Strand Selection in Mammalian Cells"  Nucleic Acid Ther. 2020, 30, 229-236.

28. M. L. Hammill, G. Islam, and J.-P. Desaulniers. "Reversible Control of RNA Interference by siRNAzos"  Org. Biomol. Chem. 2020, 18, 41-46.

29. L. Salim, G. Islam, and J.-P. Desaulniers. "Targeted Delivery and Enhanced Gene-Silencing Activity of Centrally-Modified Folic Acid-siRNA Conjugates"  Nucleic Acids Res. 2020, 48, 75-85.

30.  M. L. Hammill, A. Patel, M. A. Alla, and J.-P. Desaulniers. "Stability and Evaluation of siRNAs Labeled at the Sense Strand with a 3'-Azobenzene Unit"  Bioorg. Med. Chem. Lett. 2018, 28, 3613-3616.

31. L. Salim, C. McKim, and J.-P. Desaulniers. "Effective Carrier-Free Gene-Silencing Activity of Cholesterol-Modified siRNAs"  RSC Advances 2018, 8, 22963-22966.

32. M. L. Hammill, C. Isaacs-Trepanier, and J.-P. Desaulniers. "siRNAzos: A New Class of Azobenzene-Containing siRNAs that Can Photochemically Regulate Gene Expression" ChemistrySelect 2017, 2, 9810-9814.

33. S. G. Forrester, J. Foster, S. Robert, L. Salim, and J.-P. Desaulniers. "Efficient Synthesis of the GABAA Receptor Agonist trans-4-Aminocrotonic Acid (TACA)" Bioorg. Med. Chem. Lett. 2017, 27, 4512-4513.

34. J.-P. Desaulniers, G. Hagen, J. Anderson, C. McKim, and B. Roberts. "Effective Gene-Silencing of siRNAs that Contain Functionalized Spacer Linkages Within the Central Region"  RSC Advances 2017, 7, 3450-3454.

35. G. Hagen, B. J. Peel, J. Samis, and J.-P. Desaulniers. "Synthesis and Biological Assessment of Chemically Modified siRNAs Containing 2'-Ribose Modifications with Triazole-Linked Backbone Modifications" MedChemComm, 2015, 6, 1210-1215.

36. M. Kaji, M. Callanan, A. Kwaka, H. Nusrat, J.-P. Desaulniers, and S. G. Forrester. "A Molecular Characterization of the Agonist Binding Site of a Nematode cys-loop GABA Receptor" Br. J. Pharmacol., 2015, 172, 3737-3747.

37. B. J. Peel, G. Hagen, K. Krishnamurthy, and J.-P. Desaulniers. "Conjugation and Evaluation of Small Hydrophobic Molecules to Triazole-Linked siRNAs" ACS Med. Chem. Lett. 2015, 6, 117-122.

38. J. L. Comstock, J.-P. Desaulniers, H. N. LeBlanc, and S. L. Forbes. "New decomposition stages to describe scenarios involving the partial and complete exclusion of insects" Can. Soc. For. Sci. J. 2015, 48, 1-19.

39. S. Stadler, J.-P. Desaulniers, and S. L. Forbes. "Inter-year repeatability study of volatile organic compounds from surface decomposition of human analogues." Int. J. Legal Medicine, 2015, 129, 641-650.

40. B. J. Peel, T. C. Efthymiou, and J.-P. Desaulniers. "Synthesis of Triazole-Nucleoside Phosphoramidites and Their Use in Solid-Phase Oligonucleotide Synthesis" Curr. Protoc. Nucleic Acid Chem. 2013, 55:4.57.1-4.57.38.

41. T.C. Efthymiou, W. Gong, and J.-P. Desaulniers. "Chemical Architecture and Applications of Nucleic Acid Derivatives Containing 1,2,3-Triazole Functionalities Synthesized Via Click Chemistry" Molecules 2012, 17, 12665-12703.

42. W. Gong and J.-P. Desaulniers. "Gene-Silencing Properties of siRNAs that Contain Internal Amide-Bond Linkages" Bioorg. Med. Chem. Lett. 2012, 22, 6934-6937.

43. T.C. Efthymiou, B. Peel, V. Huynh, and J.-P. Desaulniers. "Evaluation of siRNAs that Contain Internal Variable-Length Spacer Linkages" Bioorg. Med. Chem. Lett. 2012, 22, 5590-5594.

44. W. Gong and J.-P. Desaulniers. "Synthesis and Properties of RNAs that Contain a PNA-RNA Dimer." Nucleosides Nucleotides Nucleic Acids 2012, 31, 389-400.

45. T.C. Efthymiou, V. Huynh, J. Oentoro, B. Peel, and J.-P. Desaulniers. "Efficient Synthesis and Cell-Based Silencing Activity of siRNAs that Contain Triazole Backbone Linkages" Bioorg. Med. Chem. Lett. 2012, 22, 1722-1726.

46. T.C. Efthymiou and J.-P. Desaulniers. "Synthesis and Properties of Oligonucleotides that Contain a Triazole-Linked Nucleic Acid Dimer" J. Heterocycl. Chem. 2011, 48, 533-539.

47. J.-P. Desaulniers. "Pivaloxymethyl Chloride" e-EROS - Encyclopedia of Reagents for Organic Synthesis, D. Crich, Ed.; Wiley InterScience, Chichester, March 15, 2011; DOI: 10.1002/047084289X.rn01252.

48. T.C. Efthymiou, C. Koehler, and J.-P. Desaulniers. "Disodium-2-carbamoyl-2-cyanoethylene-1,1-dithiolate" e-EROS - Encyclopedia of Reagents for Organic Synthesis, D. Crich, Ed.; Wiley InterScience, Chichester, March 15, 2011; DOI: 10.1002/047084289X.rn01251.

49. T.C. Efthymiou and J.-P. Desaulniers. "3-Chloro-3(Diphenylmethoxy)-1,1,1,5,5,5-Hexamethyltrisiloxane" e-EROS - Encyclopedia of Reagents for Organic Synthesis, D. Crich, Ed.; Wiley InterScience, Chichester, October 15, 2010; DOI: 10.1002/047084289X.rn01127.

50. J.-P. Desaulniers. "Tris(2-Acetoxyethoxy)orthoformate" e-EROS - Encyclopedia of Reagents for Organic Synthesis, D. Crich, Ed.; Wiley InterScience, Chichester, October 15, 2010; DOI: 10.1002/047084289X.rn01126.

51. L. W. Lee, C. E. Taylor, J.-P. Desaulniers, M. Zhang. J. W. Hojfeldt, Q. Pan, and A. K. Mapp. "Inhibition of ErbB2(Her2) Expression with Small Molecule Transcription Factor Mimics" Bioorg. Med. Chem. Lett. 2009, 19, 6233-6236.

52. R. J. Casey, J.-P. Desaulniers, J. W. Hojfeldt, and A. K. Mapp, "Expanding the Repertoire of Small Molecule Transcriptional Activation Domains" Bioorg. Med. Chem. 2009, 17, 1034-43.

53. J.-P. Desaulniers, Y.-C. Chang, S. Abeyguarwardena, R. Aduri, J. SantaLucia Jr, and C. S. Chow. "Pseudouridines in rRNA Helix 69 Play a Role in Loop Stacking Interactions", Org. Biomol. Chem. 2008, 6, 3892-3895.

54. M. Sumita, J.-P. Desaulniers, Y.-C. Chang, H. M.-P. Chui, L. Clos II, and C. S. Chow. "Effects of Nucleotide Substitution and Modification on the Stability and Structure of Helix 69 from 28S rRNAs", RNA 2005, 11, 1420-1429.

55. J.-P. Desaulniers, H. M.-P. Chui, and C. S. Chow. "Solution Conformation of 3-Methyluridine and 3-Methylpseudouridine", Bioorg. Med. Chem. 2005, 13, 6777-6781.

56. N. Esho, J.-P. Desaulniers, B. Davis, H. M.-P. Chui, M. S. Rao, C. S. Chow, S. Szafert, and R. Dembinski. "NMR conformational Analysis of p-Tolyl Furanopyrimidine 2'-Deoxyribonucleoside and Crystal Structure of its 3',5'-Di-O-acetyl Derivative", Bioorg. Med. Chem. 2005, 13, 1231-1238.

57. N. Hamdy, A. S. Goustin, J.-P. Desaulniers, M. Li, C. S. Chow, and A. Al-Katib. "Sheep Red Blood Cells Armed with Anti-CD20 Single-Chain Variable Fragments (scFvs) Fused to a Glycosylphosphatidylinositol (GPI) Anchor: a Strategy to Target CD20-Positive Tumor Cells", J. Immunol. Methods 2005, 297, 109-124.

58. J.-P. Desaulniers, B. Ksebati, and C. S. Chow. "Synthesis of 15N-Enriched Pseudouridine Derivatives", Org. Lett. 2003, 5, 4093-4096.

59. H. M.-P. Chui, J.-P. Desaulniers, S. Scaringe, and C.S. Chow. "Synthesis of Helix 69 of Escherichia coli 23S rRNA Containing its Natural Modified Nucleosides, m3ψ and ψ", J. Org. Chem. 2002, 67, 8847-